Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …

Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

Inherited epidermolysis bullosa is a group of genetic diseases characterized by skin fragility
and blistering on the skin and mucous membranes in response to minimal trauma …

Integrins are essential adhesion receptors found on the surfaces of all metazoan cells. As
regulators of cell migration and extracellular matrix assembly, these membrane-spanning …

Kindlins and talins are integrin-binding proteins that are critically involved in integrin
activation, an essential process for many fundamental cellular activities including cell-matrix …

Leucocytes are highly motile cells. Their ability to migrate into tissues and organs is
dependent on cell adhesion molecules. The integrins are a family of heterodimeric …

Talins are cytoplasmic adapter proteins essential for integrin‐mediated cell adhesion to the
extracellular matrix. Talins control the activation state of integrins, link integrins to …

Integrins are transmembrane receptors that mediate cell-cell and cell-extracellular matrix
adhesion. Although all integrins can undergo activation (affinity change for ligands), the …