Methionine Restriction Diets: Unravelling Biological Mechanisms and Enhancing Brain Health

Y Liu, J Guo, H Cheng, J Wang, Y Tan, J Zhang… - Trends in Food Science …, 2024 - Elsevier
Abstract Background Methionine (Met) uptake and metabolism are integral to various
cellular functions. Excessive intake of Met from human diets can lead to numerous health …

[HTML][HTML] Metabolic Adaptations in Cancer and the Host Using Drosophila Models and Advanced Tools

E Saez-Carrion, M Aguilar-Aragon, L García-López… - Cells, 2024 - mdpi.com
Cancer is a multifactorial process involving genetic, epigenetic, physiological, and metabolic
changes. The ability of tumours to regulate new reactive pathways is essential for their …

Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila

Y Ikegawa, C Combet, M Groussin, V Navratil… - The EMBO …, 2023 - embopress.org
Cells need to sense stresses to initiate the execution of the dormant cell death program.
Since the discovery of the first BH3‐only protein Bad, BH3‐only proteins have been …

Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes

HM Ciesielski, H Nishida, T Takano, A Fukuhara… - PLoS …, 2022 - journals.plos.org
Many adult tissues are composed of differentiated cells and stem cells, each working in a
coordinated manner to maintain tissue homeostasis during physiological cell turnover. Old …

pH-regulating nanoplatform for the “double channel chase” of tumor cells by the synergistic cascade between chlorine treatment and methionine-depletion starvation …

Y Jiang, Y Tan, K Xiao, X Li, K Shao… - … applied materials & …, 2021 - ACS Publications
During rapid proliferation and metabolism, tumor cells show a high dependence on
methionine. The deficiency of methionine exhibits significant inhibition on tumor growth …

Oncogenic stress‐induced Netrin is a humoral signaling molecule that reprograms systemic metabolism in Drosophila

M Okada, T Takano, Y Ikegawa, H Ciesielski… - The EMBO …, 2023 - embopress.org
Cancer exerts pleiotropic, systemic effects on organisms, leading to health deterioration and
eventually to organismal death. How cancer induces systemic effects on remote organs and …

Comparative Study on the Mechanism of Macrophage Activation Induced by Polysaccharides from Fresh and Dried Longan

S Wang, X Chen, Q Li, Y Zhang, Y Rong, Y Feng, H Liu… - Nutrients, 2024 - mdpi.com
Longan (Dimcarpus longan Lour.) is a kind of traditional fruit used as a medicine and a food.
Fresh longan is primarily consumed as a fruit, whereas dried longan is commonly employed …

Necrosensor: a genetically encoded fluorescent sensor for visualizing necrosis in Drosophila

H Nishida, AB Albero, K Onoue, Y Ikegawa… - Biology …, 2024 - journals.biologists.com
Historically, necrosis has been considered a passive process, which is induced by extreme
stress or damage. However, recent findings of necroptosis, a programmed form of necrosis …

Revealing the Preventable Effects of Fu-Zheng-Qu-Xie Decoction against Recurrence and Metastasis of Postoperative Early-Stage Lung Adenocarcinoma Based on …

Y Zhang, K Ma, L Jiang, L Xu, Y Luo, J Wu, Y Li - ACS omega, 2023 - ACS Publications
Fu-Zheng-Qu-Xie (FZQX) decoction is a traditional Chinese herbal prescription for the
treatment of lung cancer and exerts proapoptotic and immunomodulatory effects. It has been …

A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells

S Sulekh, Y Ikegawa, S Naito, A Oji… - Life Science …, 2024 - life-science-alliance.org
Cell death and proliferation are at a glance dichotomic events, but occasionally coupled.
Caspases, traditionally known to execute apoptosis, play non-apoptotic roles, but their exact …