The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the
cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions …

Signal peptides (SP) are short peptides located in the N-terminal of proteins, carrying
information for protein secretion. They are ubiquitous to all prokaryotes and eukaryotes. SPs …

Autosomal-dominant polycystic kidney disease (ADPKD) is a common, progressive, adult-
onset disease that is an important cause of end-stage renal disease (ESRD), which requires …

Protein folding in the endoplasmic reticulum (ER) is monitored by ER quality control (ERQC)
mechanisms. Proteins that pass ERQC criteria traffic to their final destinations through the …

A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a
protein-conducting channel, allowing polypeptides to be transferred across or integrated into …

A decisive step in the biosynthesis of many proteins is their partial or complete translocation
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …

The unifying feature of all proteins that are transported out of the cytoplasm of gram-negative
bacteria by the general secretory pathway (GSP) is the presence of a long stretch of …

Eukaryotes use the process of autophagy, in which structures targeted for
lysosomal/vacuolar degradation are sequestered into double-membrane autophagosomes …

The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse
array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum …

Bacilli secrete numerous proteins into the environment. Many of the secretory proteins, their
export signals, and their processing steps during secretion have been characterized in …