Invasive fungal infections in humans are generally associated with high mortality, making
the choice of antifungal drug crucial for the outcome of the patient. The limited spectrum of …

The production of peptides and small proteins with microbicidal activity collectively called
antimicrobial peptides (AMPs) is commonly considered to be a primitive mechanism of …

As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

The Candida albicans cell wall maintains the structural integrity of the organism in addtion to
providing a physical contact interface with the environment. The major components of the …

Antimicrobial peptides are a vital component of the innate immune system of all eukaryotic
organisms and many of these peptides have potent antifungal activity. They have potential …

The recognition of fungal cells by the host immune system is key during the establishment of
a protective anti-fungal response. Even though the immune system has evolved a vast …

Histatins are salivary cationic peptides that provide the first line of defense against oral
candidiasis caused by Candida albicans. This minireview presents a critical evaluation of …

Oropharyngeal candidiasis (OPC) occurs in a diverse group of patients. Risk factors for OPC
include the use of dentures, corticosteroid inhalers, cigarettes, broad-spectrum antibiotics …

Over the last years, antimicrobial peptides (AMPs) have been the focus of intense research
toward the finding of a viable alternative to current antifungal drugs. Defensins are one of the …

The cell wall of Candida albicans consists of an internal skeletal layer and an external
protein coat. This coat has a mosaic-like nature, containing c. 20 different protein species …