Natural products continue to play a pivotal role in drug-discovery efforts and in the
understanding of human health. The ability to extend nature's chemistry through …

Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …

There is a constant need for new and improved drugs to combat infectious diseases, cancer,
and other major life-threatening conditions. The recent development of genomics-guided …

In this article strategies for the design and synthesis of natural product analogues are
summarized and illustrated with some selected examples. Proven strategies include …

Organofluorines represent a rapidly expanding proportion of molecules that are used in
pharmaceuticals, diagnostics, agrochemicals, and materials. Despite the prevalence of …

Both natural products and synthetic organofluorines play important roles in the discovery
and design of pharmaceuticals. The combination of these two classes of molecules has the …

Covering: up through August 2011 This review covers the emerging biosynthetic role of
crotonyl-CoA carboxylase/reductase (CCR) homologs in extending the structural and …

Nature is providing a bountiful pool of valuable secondary metabolites, many of which
possess therapeutic properties. However, the discovery of new bioactive secondary …

Thioesters play essential roles in many biosynthetic pathways to fatty acids, esters,
polyketides, and non-ribosomal peptides. Coenzyme A (CoA) and related …

Covering: 2003 to July 2015 for polyketide synthase starter units and 2012 to September
2015 for polyketide synthase extender units This highlight provides an overview of recent …