Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms
N Hurvitz, N Elkhateeb, T Sigawi, L Rinsky-Halivni… - Frontiers in …, 2022 - frontiersin.org
Aging is a complex biological process with multifactorial nature underlined by genetic,
environmental, and social factors. In the present paper, we review several mechanisms of …
environmental, and social factors. In the present paper, we review several mechanisms of …
Epigenetic and transcriptional variability shape phenotypic plasticity
Epigenetic and transcriptional variability contribute to the vast diversity of cellular and
organismal phenotypes and are key in human health and disease. In this review, we …
organismal phenotypes and are key in human health and disease. In this review, we …
Transcriptome profiling analyses in psoriasis: a dynamic contribution of keratinocytes to the pathogenesis
Psoriasis is an immune-mediated inflammatory skin disease with a complex etiology
involving environmental and genetic factors. A better insight into related genomic alteration …
involving environmental and genetic factors. A better insight into related genomic alteration …
[HTML][HTML] Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age–an exposome-based approach in 5 …
Background Studies looking at associations between environmental chemicals and child
behaviour usually consider only one exposure or family of exposures. Objective This study …
behaviour usually consider only one exposure or family of exposures. Objective This study …
Equivalent DNA methylation variation between monozygotic co-twins and unrelated individuals reveals universal epigenetic inter-individual dissimilarity
Background Although the genomes of monozygotic twins are practically identical, their
methylomes may evolve divergently throughout their lifetime as a consequence of factors …
methylomes may evolve divergently throughout their lifetime as a consequence of factors …
Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes
RF Pérez, P Santamarina, JR Tejedor… - Journal of translational …, 2019 - Springer
Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
Sequence features of retrotransposons allow for epigenetic variability
KR Costello, A Leung, C Trac, M Lee, M Basam… - Elife, 2021 - elifesciences.org
Transposable elements (TEs) are mobile genetic elements that make up a large fraction of
mammalian genomes. While select TEs have been co-opted in host genomes to have …
mammalian genomes. While select TEs have been co-opted in host genomes to have …
Aging and cancer epigenetics: Where do the paths fork?
Aging and cancer are clearly associated processes, at both the epidemiological and
molecular level. Epigenetic mechanisms are good candidates to explain the molecular links …
molecular level. Epigenetic mechanisms are good candidates to explain the molecular links …
Epigenetic dysregulation of genes related to synaptic long-term depression among adolescents with depressive disorder and sleep symptoms
AJ Ämmälä, AS Urrila, A Lahtinen, O Santangeli… - Sleep medicine, 2019 - Elsevier
Objectives This study aimed to test the hypothesis that sleep and depression have
independent effects on brain development and plasticity in adolescents, and that these …
independent effects on brain development and plasticity in adolescents, and that these …