Protein subcellular localization is tightly controlled and intimately linked to protein function in
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

The centrosome provides an intracellular anchor for the cytoskeleton, regulating cell
division, cell migration, and cilia formation. We used spatial proteomics to elucidate protein …

The study of protein localisation has greatly benefited from high-throughput methods
utilising cellular fractionation and proteomic profiling. Hyperplexed Localisation of Organelle …

Dynamic change in subcellular localization of signaling proteins is a general concept that
eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry …

Computational proteomics is the data science concerned with the identification and
quantification of proteins from high-throughput data and the biological interpretation of their …

Spatial proteomics is an interdisciplinary field that investigates the localization and dynamics
of proteins, and it has gained extensive attention in recent years, especially the subcellular …

The AP-5 adaptor protein complex is presumed to function in membrane traffic, but so far
nothing is known about its pathway or its cargo. We have used CRISPR-Cas9 to knock out …

Abstract Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose
function has largely remained elusive. In humans, AP-4 deficiency causes a severe …

Adaptor protein (AP) complexes are heterotetramers that select cargo for inclusion into
transport vesicles. Five AP complexes (AP-1 to AP-5) have been described, each with a …