Detection and analysis of chiral molecules as disease biomarkers

Y Liu, Z Wu, DW Armstrong, H Wolosker… - Nature Reviews …, 2023 - nature.com
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Reactive oxygen nano-generators for cancer therapy

D Kalyane, D Choudhary, S Polaka, H Goykar… - Progress in Materials …, 2022 - Elsevier
Reactive oxygen species (ROS) play a vital role in the biological process. Interestingly,
based on the concentration of the ROS level, they can be beneficial or detrimental to tumor …

D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain

ER Semenza, MM Harraz… - Proceedings of the …, 2021 - National Acad Sciences
d-amino acids are increasingly recognized as important signaling molecules in the
mammalian central nervous system. However, the d-stereoisomer of the amino acid with the …

A guide to genetically encoded tools for the study of H2O2

DD Smolyarova, OV Podgorny, DS Bilan… - The FEBS …, 2022 - Wiley Online Library
Cell metabolism heavily relies on the redox reactions that inevitably generate reactive
oxygen species (ROS). It is now well established that ROS fluctuations near basal levels …

Roles of N-methyl-D-aspartate receptors (NMDARs) in epilepsy

S Chen, D Xu, L Fan, Z Fang, X Wang… - Frontiers in Molecular …, 2022 - frontiersin.org
Epilepsy is one of the most common neurological disorders characterized by recurrent
seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N …

L-serine synthesis via the phosphorylated pathway in humans

G Murtas, GL Marcone, S Sacchi… - Cellular and Molecular Life …, 2020 - Springer
L-serine is a nonessential amino acid in eukaryotic cells, used for protein synthesis and in
producing phosphoglycerides, glycerides, sphingolipids, phosphatidylserine, and …

The role of D-amino acids in Alzheimer's disease

L Piubelli, G Murtas, V Rabattoni… - Journal of Alzheimer's …, 2021 - content.iospress.com
Abstract Alzheimer's disease (AD), the main cause of dementia worldwide, is characterized
by a complex and multifactorial etiology. In large part, excitatory neurotransmission in the …

[HTML][HTML] Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients

A Di Maio, T Nuzzo, L Gilio, M Serra, F Buttari… - Neurobiology of …, 2023 - Elsevier
L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic
processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) …

Colorimetric quantification of sodium benzoate in food by using d-amino acid oxidase and 2D metal organic framework nanosheets mediated cascade enzyme …

H Zhang, H Yang, P Liu, X Qin, G Liu - Talanta, 2022 - Elsevier
A rapid colorimetric method for detecting sodium benzoate in food products was established
based on the d-amino acid oxidase (DAAO) and 2D metal organic framework (2D MOF) …

Reactive oxygen species as a double‐edged sword: The role of oxidative enzymes in antitumor therapy

E Rosini, L Pollegioni - BioFactors, 2022 - Wiley Online Library
A number of approaches have been developed over the years to manage cancer, such as
chemotherapy using low‐molecular‐mass molecules and radiotherapy. Here, enzymes can …