D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of
many preclinical studies to ascertain the nature of its metabolism, its regional and cellular …

D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …

Abstract Alzheimer's disease (AD), the main cause of dementia worldwide, is characterized
by a complex and multifactorial etiology. In large part, excitatory neurotransmission in the …

Abstract The N‐Methyl D‐Aspartic acid (NMDA) receptors (NMDAR) are key tetrameric
ionotropic glutamate receptors that transduce glutamatergic signals throughout the central …

Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are utilized as
coenzymes in many biochemical reduction-oxidation reactions owing to the ability of the …

Over the years, accumulating evidence has indicated that D-serine represents the
endogenous ligand for the glycinemodulatory binding site on the NR1 subunit of N-methyl-D …

Since d-amino acids were identified in mammals, d-serine has been one of the most
extensively studied “unnatural amino acids”. This brain-enriched transmitter-like molecule …

D-enantiomers of amino acids (D-AAs) are only present in low amounts in nature, frequently
at trace levels, and for this reason, their biological function was undervalued for a long time …

Numerous studies over the last several years have shown that d-amino acids, especially d-
serine, have been related to brain and neurological disorders. Acknowledged neurological …

Abstract α-Amino acids are present in two opposite configurations due to the presence of a
central carbon atom which is a chiral center. While l-amino acids are present in large …