Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the
nuclear DNA. As such, variations in nuclear gene expression as a consequence of …

Next-generation sequencing (NGS) technology, with its high-throughput capacity and low
cost, has developed rapidly in recent years and become an important analytical tool for …

Forensic epigenetics, ie, investigating epigenetics variation to resolve forensically relevant
questions unanswerable with standard forensic DNA profiling has been gaining substantial …

Designed as an accessible introduction to basic scientific principles and their application in
professional practice, Forensic Biology provides a concise overview of the field. Focusing …

Due to its convenience, the blood is commonly used in epigenomic studies, but its
heterogeneous nature leads to interpretation difficulties, given the now widely recognized …

DNA methylation of cytosine residues is a stable epigenetic alteration, beginning as early as
foetal development in the uterus and continuously evolving throughout life. DNA methylation …

Human genetic variation is a major resource in forensics, but does not allow all forensically
relevant questions to be answered. Some questions may instead be addressable via …

Monozygotic (MZ) twins share the same STR profile, demonstrating a practical problem in
forensic casework. DNA methylation has provided a suitable resource for MZ twin …

Epigenetics is an emerging area of interest in forensic science. DNA methylation, a type of
epigenetic modification, can be applied to chronological age estimation, identical twin …

DNA methylation at cytosines followed by guanines, CpGs, forms one of the multiple layers
of epigenetic mechanisms controlling and modulating gene expression through chromatin …