High‐Precision Synthesis of RNA‐Loaded Lipid Nanoparticles for Biomedical Applications
The recent development of RNA‐based therapeutics in delivering nucleic acids for gene
editing and regulating protein translation has led to the effective treatment of various …
editing and regulating protein translation has led to the effective treatment of various …
[HTML][HTML] Interdisciplinary advances reshape the delivery tools for effective NASH treatment
L Chen, Y Wang - Molecular Metabolism, 2023 - Elsevier
Background Nonalcoholic steatohepatitis (NASH), a severe systemic and inflammatory
subtype of nonsalcoholic fatty liver disease, eventually develops into cirrhosis and …
subtype of nonsalcoholic fatty liver disease, eventually develops into cirrhosis and …
Hydroxypropyl-beta-Cyclodextrin embedded resveratrol regulates gut microbiota to prevent NAFLD via activating AMPK signaling pathway
W Ke, J Huang, Y Zhong, Y Shi, F Yan, D Huang, Y Wu… - Food Bioscience, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become a globally rising issue that can cause
liver-related morbidity and mortality. Recent studies have revealed that a high-fat diet (HFD) …
liver-related morbidity and mortality. Recent studies have revealed that a high-fat diet (HFD) …
[HTML][HTML] Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions
Lipopolysaccharide binding protein (LBP) knockout mice models are protected against the
deleterious effects of major acute inflammation but its possible physiological role has been …
deleterious effects of major acute inflammation but its possible physiological role has been …
Promoting intestinal antimicrobial defense and microbiome symbiosis contributes to IL-22-mediated protection against alcoholic hepatitis in mice
Background The hepatoprotective effect of interleukin 22 (IL-22) has been reported in
several models of liver injuries, including alcohol-associated liver disease (ALD). However …
several models of liver injuries, including alcohol-associated liver disease (ALD). However …
Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis
Q Zhang, X Shen, X Yuan, J Huang, Y Zhu… - Nature …, 2024 - nature.com
Oxidative stress-induced lipid accumulation is mediated by lipid droplets (LDs) homeostasis,
which sequester vulnerable unsaturated triglycerides into LDs to prevent further …
which sequester vulnerable unsaturated triglycerides into LDs to prevent further …
6-Shogaol Ameliorates Liver Inflammation and Fibrosis in Mice on a Methionine-and Choline-Deficient Diet by Inhibiting Oxidative Stress, Cell Death, and …
AY Yang, K Kim, HH Kwon, J Leem, JE Song - Molecules, 2024 - mdpi.com
Non-alcoholic steatohepatitis (NASH) is becoming an increasingly serious global health
threat, distinguished by hepatic lipid accumulation, inflammation, and fibrosis. There is a …
threat, distinguished by hepatic lipid accumulation, inflammation, and fibrosis. There is a …
Nanomedical research and development in Spain: improving the treatment of diseases from the nanoscale
P Fernández-Gómez… - … in Bioengineering and …, 2023 - frontiersin.org
The new and unique possibilities that nanomaterials offer have greatly impacted
biomedicine, from the treatment and diagnosis of diseases, to the specific and optimized …
biomedicine, from the treatment and diagnosis of diseases, to the specific and optimized …
The relevance of intestinal barrier dysfunction, antimicrobial proteins and bacterial endotoxin in metabolic dysfunction‐associated steatotic liver disease
I Bergheim… - European Journal of …, 2024 - Wiley Online Library
Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a leading
cause of end‐stage liver disease associated with increased mortality and cardiovascular …
cause of end‐stage liver disease associated with increased mortality and cardiovascular …
The Coming Age of Antisense Oligos for the Treatment of Hepatic Ischemia/Reperfusion (IRI) and Other Liver Disorders: Role of Oxidative Stress and Potential …
S Yao, A Kasargod, R Chiu, TR Torgerson… - Antioxidants, 2024 - mdpi.com
Imbalances in the redox state of the liver arise during metabolic processes, inflammatory
injuries, and proliferative liver disorders. Acute exposure to intracellular reactive oxygen …
injuries, and proliferative liver disorders. Acute exposure to intracellular reactive oxygen …