Chagas disease (CD) caused by the protozoan Trypanosoma cruzi affects more than six
million people worldwide. Treatment is restricted to benznidazole (Bz) and nifurtimox (Nf) …

Background Historically, plants have proven their value as a source of phytochemicals with
therapeutic potentials and recently they play an important role in the discovery of novel …

The interest of many investigators in naphthoquinones is due to their broad-range of
biological actions from phytotoxic to fungicidal. The main aim of this work was to investigate …

Plumbago scandens L.(Plumbaginaceae) occurs in all regions of Brazil. It has been
described as toxic to cattle and goats. Caustic lesions in the upper digestive tract …

Abstract The solubility of 1, 4-naphthoquinone, plumbagin, lawsone, and juglone in
supercritical carbon dioxide was determined spectroscopically at 40° C, and in the pressure …

Centrifugal liquid–liquid partition chromatography presents significant advantages for the
separation and purification of plant metabolites owing to the short operational time of the …

Plumbago scandens L. is a Brazilian tropical/subtropical species that occurs along the coast.
Chemically it is mainly represented by naphthoquinones, flavonoids, terpenoids and …

The liver is an important organ in the body; its diseases are considered the major causes of
morbidity and mortality around the world. Hepatotoxic chemicals cause damage to liver …

The aim of the work was to optimize the high performance liquid chromatography coupled
with a diode array detector for the determination of naphthoquinones (1, 4-naphthoquinone …

Três naftoquinona,(11S, 13S, 16R)-cordiaquinona J ((+)-cordiaquinona J), 6-[10-(12, 12-
dimetil-13α-hidroxi-16-metil-ciclohexil]-1, 4-naftalenodiona (cordiaquinona L) e 5-metil-6-[10 …