The emergence of Zika virus (ZIKV) as a major public health threat has focused research on
understanding virus biology and developing a suite of strategies for disease intervention …

Dengue is the most prevalent arthropod-borne viral disease, caused by dengue virus, a
member of the Flaviviridae family. Its worldwide incidence is now a major health problem …

Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for
significant mortality and morbidity worldwide. The genus comprises more than seventy …

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne human pathogen that causes
chikungunya fever, which is typically accompanied by severe joint pain. In Asia, serological …

Flaviviruses are enveloped, single-stranded RNA viruses that widely infect many animal
species. The envelope protein, a structural protein of flavivirus, plays an important role in …

Covering: up to April 2014 The development of drugs with broad-spectrum antiviral activities
is a long pursued goal in drug discovery. It has been shown that blocking co-opted host …

Dengue is a major global health threat causing 390 million dengue infections and 25,000
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …

Abstract Dengue virus (DENV) infects~ 400 million people annually. There is no licensed
vaccine or therapeutic drug. Only a small fraction of the total DENV-specific antibodies in a …

Dengue virus (DENV) consists of four serotypes in the family Flaviviridae and is a causative
agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. DENV is …

The dengue virus and related flaviviruses are an increasing global health threat. In this
perspective, we comment on and review medicinal chemistry efforts aimed at the prevention …