Wnt signaling pathway is one of the most important signaling pathways. The complexity of
Wnt signals and their functional role is crucial in development and growth. It is the most …

The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …

More is becoming known about so-called noncanonical Wnt pathways that signal
independently of β-catenin. Here we review recent developments in both the functions and …

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the
tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP …

Cystic renal diseases are caused by mutations of proteins that share a unique subcellular
localization: the primary cilium of tubular epithelial cells. Mutations of the ciliary protein …

Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling
pathways. These pathways regulate crucial processes during various stages of development …

Most, if not all, cell types and tissues display several aspects of polarization. In addition to
the ubiquitous epithelial cell polarity along the apical-basolateral axis, many epithelial …

WNT/planar cell polarity (PCP) signaling pathway controls tissue polarity and cell movement
through the activation of RHOA, c-Jun N-terminal kinase (JNK), and nemo-like kinase (NLK) …

Abstract Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved
mechanism that polarizes cells along specific axes in a tissue. Genetic screens in …

Planar cell polarization entails establishment of cellular asymmetries within the tissue plane.
An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra-and …