The S100 family of proteins contains 25 known members that share a high degree of
sequence and structural similarity. However, only a limited number of family members have …

Adult-onset Still's disease (AoSD) is a rare but clinically well-known, polygenic, systemic
autoinflammatory disease. Owing to its sporadic appearance in all adult age groups with …

Inflammasomes are innate immune sensors that respond to pathogen-and damage-
associated signals with caspase-1 activation, interleukin (IL)-1β and IL-18 secretion, and …

Background Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-
threatening hyperinflammatory syndrome that occurs after primary SARS-CoV-2 infection …

Pyrin responds to pathogen signals and loss of cellular homeostasis by forming an
inflammasome complex that drives the cleavage and secretion of interleukin-1β (IL-1β) …

Systemic juvenile idiopathic arthritis (sJIA) has long been recognized as unique among
childhood arthritides, because of its distinctive clinical and epidemiological features …

Systemic juvenile idiopathic arthritis (sJIA) is a very distinctive subtype of juvenile idiopathic
arthritis (JIA) with unique clinical manifestations, associated complications, and therapeutic …

Familial Mediterranean fever (FMF) is the most common of the hereditary periodic fever
syndromes. Although the typical clinical course of FMF is characterized by bouts of painful …

Alarmins (also known as danger signals) are endogenous molecules that are released to
the extracellular milieu after infection or tissue damage. Extracellular alarmins interact with …

Canakinumab (ACZ885, Ilaris) is a human anti-IL-1β monoclonal antibody developed by
Novartis. Its mode of action is based on the neutralization of IL-1β signaling, resulting in …