Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Eukaryotic cells contain various Ca2+-effector proteins that mediate cellular responses to
changes in intracellular Ca2+ levels. A unique class of these proteins—annexins—can bind …

Ca2+ is an essential ion in all organisms, where it plays a crucial role in processes ranging
from the formation and maintenance of the skeleton to the temporal and spatial regulation of …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

Annexins are a well-known multigene family of Ca2+-regulated phospholipid-binding and
membrane-binding proteins. Recent work employing annexin-knockdown or-knockout …

Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

The S100 proteins comprise at least 25 members, forming the largest group of EF-hand
signalling proteins in humans. Although the proteins are expressed in many tissues, each …

The pathophysiology of depression remains enigmatic, although abnormalities in serotonin
signaling have been implicated. We have found that the serotonin 1B receptor [5 …

Abstract Two-pore-domain K+ (K2P) channel subunits are made up of four transmembrane
segments and two pore-forming domains that are arranged in tandem and function as either …

Breast cancer stem cells (BCSCs) play a critical role in cancer recurrence and metastasis.
Chemotherapy induces BCSC specification through increased expression of pluripotency …