Polyglutamine/poly (Q) diseases are a group nine hereditary neurodegenerative disorders
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …

Simple Summary In search of common pathophysiological events among
neurodegenerative diseases, arginine methylation of proteins has been revealed as a …

A major mechanism to modulate the biological activities of the androgen receptor (AR)
involves a growing number of post-translational modifications (PTMs). In this review we …

Synthetic glucocorticoids (GC), such as dexamethasone, are extensively used to treat
chronic inflammation and autoimmune disorders. However, long-term treatments are limited …

Currently, nine polyglutamine (polyQ) expansion diseases are known. They include
spinocerebellar ataxias (SCA1, 2, 3, 6, 7, 17), spinal and bulbar muscular atrophy (SBMA) …

Spinal and bulbar muscular atrophy (SBMA) is a slowly progressing neuromuscular disease
caused by a polyglutamine (polyQ)-encoding CAG trinucleotide repeat expansion in the …

Given the large number of genes significantly associated with risk for neuropsychiatric
disorders, a critical unanswered question is the extent to which diverse mutations …

Background and aims Hepatic lipogenesis is elevated in nutrient abundant conditions to
convert the excess carbohydrate into triacylglycerol (TAG). Fatty acyl moiety of TAG is …

The feed-forward loop between the transcription factors Ppar-gamma and C/ebp-alpha is
critical for lineage commitment during adipocytic differentiation. Ppar-gamma interacts with …

The clinical characteristics of SBMA, also known as Kennedy's disease (OMIM 313200),
were initially documented by Dr. H Kawahara in the 18th century and a hundred years later …