Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-
directed repair (HDR) using high concentrations of double-stranded DNA (dsDNA) with …

DNA origami may enable more versatile gene delivery applications through its ability to
create custom nanoscale objects with specific targeting, cell-invading, and intracellular …

The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR‐
related protein 9 (Cas9) genome editing system has attracted much attention due to its …

The physical and chemical properties of synthetic DNA have transformed this prototypical
biopolymer into a versatile nanoscale building block material in the form of DNA …

DNA origami has played an important role in various biomedical applications, including
biosensing, bioimaging, and drug delivery. However, the function of the long DNA scaffold …

Genetic engineering faces persistent challenges in achieving precise Deoxyribonucleic acid
(DNA) cleavage, especially with the limitations associated with current enzyme‐based …

DNA origami enables the creation of complex 3D shapes from genetic material. Future uses
could include the delivery of genetic instructions to cells, but nuclear import remains a major …

DNA nanostructures have played an important role in the development of novel drug
delivery systems. Herein, we report a DNA origami‐based CRISPR/Cas9 gene editing …

Synthetic gene networks in mammalian cells are currently limited to either protein-based
transcription factors or RNA-based regulators. Here, we demonstrate a regulatory approach …

Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize
antigens and enhance humoral immunity through multivalent antigen display. However, P …