Knots appear in a wide variety of biophysical systems, ranging from biopolymers, such as
DNA and proteins, to macroscopic objects, such as umbilical cords and catheters. Although …

During the random cyclization of long polymer chains, knots of different types are formed.
We investigated experimentally the distribution of knot types produced by random cyclization …

The DNA of all organisms has a complex and essential topology. The three topological
properties of naturally occurring DNA are supercoiling, catenation, and knotting. Although …

Mutants in bacterial topoisomerase(topo) IV are deficient in chromosomal partitioning. To
investigate the basis of this phenotype, we examined plasmid DNA topology in conditionally …

E. coli RecQ protein is a multifunctional helicase with homologs that include the S.
cerevisiae Sgs1 helicase and the H. sapiens Wrn and Blm helicases. Here we show that …

Given a “short” piece of rope, one can tie only “simple” knots. We make this precise by
modeling “rope” as a solid tube of constant radius about a smooth core. The complexity of a …

The product topology of Xer-mediated site-specific recombination at plasmid sites has been
determined. The product of deletion at pSC101 psi is a right-handed antiparallel 4-noded …

Though knotting and entanglement have been observed in DNA and proteins, their
existence in RNA remains an enigma. Synthetic RNA topological structures are significant …

Abstract We used a Monte Carlo method to study the conformational properties of catenanes
between two nicked DNA rings. We calculated the writhe induced by catenation as a …

Co-orientation of replication origins is the most common organization found in nature for
multimeric plasmids. Streptococcus pyogenes broad-host-range plasmid pSM19035 and …