Background Hippocrates flagged the value of sleep for good health. Nonetheless,
historically, researchers with an interest in developmental psychopathology have largely …

Angelman syndrome is characterized by severe developmental delay, speech impairment,
gait ataxia and/or tremulousness of the limbs, and a unique behavioral phenotype that …

In 1995, a consensus statement was published for the purpose of summarizing the salient
clinical features of Angelman syndrome (AS) to assist the clinician in making a timely and …

This review describes recent research in pediatric sleep disorders associated with
neurodevelopmental disabilities (NDDs) and their treatment. NDDs affect more than 2% of …

Angelman syndrome (AS) is a severe genetic disorder caused by mutations or deletions of
the maternally inherited UBE3A gene. UBE3A encodes an E3 ubiquitin ligase that is …

Sleep disturbances are extremely prevalent in children with neurodevelopmental disorders
compared to typically developing children. The diagnostic criteria for many …

Angelman syndrome is a neurogenetic disorder characterized by the loss or reduction of the
ubiquitin-protein ligase E3A enzyme. Angelman syndrome results from a deletion or …

Background Sleep spindles are a marker of stage 2 NREM sleep that are linked to learning
& memory and are altered by many neurological diseases. Although visual inspection of the …

The UBE3A gene is part of the chromosome 15q11-q13 region that is frequently deleted or
duplicated, leading to several neurodevelopmental disorders (NDD). Angelman syndrome …

Background Angelman syndrome (AS) is a rare disorder with a relatively well-defined
phenotype. Despite this, very little is known regarding the unmet clinical needs and burden …