Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Diabetic retinopathy (DR) is a common and devastating microvascular complication of
diabetes and a major cause of acquired blindness in young adults. Advanced glycation end …

Lifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease
(NAFLD). This randomised controlled single-blind clinical trial investigated the effect of …

Aims Recent findings have instituted the role of hyperglycemia-related AGE/RAGE and NF-
κB in instigating reactive oxygen species (ROS) mediated mitochondrial dysfunction and …

Background Advanced glycation end-products (AGEs) and their interaction with the receptor
for advanced glycation end-products (RAGE) play a pivotal role in the development and …

Advanced glycation end-products (AGEs) have been implicated in chronic hyperglycemia
and age-related diseases. Endogenous AGEs produced by humans generate oxidative …

Aging is associated with a variety of morphological and functional changes in the liver.
Oxidative stress and inflammation are now widely accepted as the main mechanisms …

The physiological significance of innate immune signaling lies primarily in its role in host
defense against invading pathogens. It is becoming increasingly clear that innate immune …

Background Multiple pathogenetic mechanisms are involved in the genesis of various
microvascular and macrovascular complications of diabetes mellitus. Of all these, advanced …

Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder whose current rapidly
expanding prevalence is causing it to develop into a major global health concern. NAFLD is …