Methylglyoxal and its adducts: Induction, repair, and association with disease
SWT Lai, EDJ Lopez Gonzalez, T Zoukari… - Chemical research in …, 2022 - ACS Publications
Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …
Involvement of advanced glycation end products in the pathogenesis of diabetic retinopathy
J Xu, LJ Chen, J Yu, HJ Wang, F Zhang… - Cellular Physiology and …, 2018 - karger.com
Diabetic retinopathy (DR) is a common and devastating microvascular complication of
diabetes and a major cause of acquired blindness in young adults. Advanced glycation end …
diabetes and a major cause of acquired blindness in young adults. Advanced glycation end …
Improvements in clinical characteristics of patients with non-alcoholic fatty liver disease, after an intervention based on the Mediterranean lifestyle: a randomised …
CN Katsagoni, GV Papatheodoridis… - British Journal of …, 2018 - cambridge.org
Lifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease
(NAFLD). This randomised controlled single-blind clinical trial investigated the effect of …
(NAFLD). This randomised controlled single-blind clinical trial investigated the effect of …
Naringin ameliorates type 2 diabetes mellitus-induced steatohepatitis by inhibiting RAGE/NF-κB mediated mitochondrial apoptosis
Aims Recent findings have instituted the role of hyperglycemia-related AGE/RAGE and NF-
κB in instigating reactive oxygen species (ROS) mediated mitochondrial dysfunction and …
κB in instigating reactive oxygen species (ROS) mediated mitochondrial dysfunction and …
[HTML][HTML] Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 …
J Sabbatinelli, S Castiglione, F Macrì, A Giuliani… - Cardiovascular …, 2022 - Springer
Background Advanced glycation end-products (AGEs) and their interaction with the receptor
for advanced glycation end-products (RAGE) play a pivotal role in the development and …
for advanced glycation end-products (RAGE) play a pivotal role in the development and …
Clinical/translational aspects of advanced glycation end-products
C Zeng, Y Li, J Ma, L Niu, FR Tay - Trends in Endocrinology & Metabolism, 2019 - cell.com
Advanced glycation end-products (AGEs) have been implicated in chronic hyperglycemia
and age-related diseases. Endogenous AGEs produced by humans generate oxidative …
and age-related diseases. Endogenous AGEs produced by humans generate oxidative …
D-galactose-induced liver aging model: Its underlying mechanisms and potential therapeutic interventions
Aging is associated with a variety of morphological and functional changes in the liver.
Oxidative stress and inflammation are now widely accepted as the main mechanisms …
Oxidative stress and inflammation are now widely accepted as the main mechanisms …
Innate immune signaling in nonalcoholic fatty liver disease and cardiovascular diseases
The physiological significance of innate immune signaling lies primarily in its role in host
defense against invading pathogens. It is becoming increasingly clear that innate immune …
defense against invading pathogens. It is becoming increasingly clear that innate immune …
AGEs accumulation with vascular complications, glycemic control and metabolic syndrome: A narrative review
R Pal, SK Bhadada - Bone, 2023 - Elsevier
Background Multiple pathogenetic mechanisms are involved in the genesis of various
microvascular and macrovascular complications of diabetes mellitus. Of all these, advanced …
microvascular and macrovascular complications of diabetes mellitus. Of all these, advanced …
Nonalcoholic fatty liver disease: lifestyle and quality of life
Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder whose current rapidly
expanding prevalence is causing it to develop into a major global health concern. NAFLD is …
expanding prevalence is causing it to develop into a major global health concern. NAFLD is …