Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

Astrocytes are abundant within mature neural circuits and are involved in brain disorders.
Here, we summarize our current understanding of astrocytes and Huntington's disease (HD) …

The unique perisynaptic distribution of postsynaptic metabotropic glutamate receptors
(mGluRs) at excitatory synapses is predicted to directly shape synaptic function, but …

'Simplicity is prerequisite for reliability'(EW Dijkstra [1]) Presynaptic action potentials trigger
the fusion of vesicles to release neurotransmitter onto postsynaptic neurons. Each release …

Designer receptors exclusively activated by designer drug (DREADDs) are a novel tool with
the potential to bidirectionally drive cellular, circuit, and ultimately, behavioral changes. We …

Traditional pre-publication peer review of scientific output is a slow, inefficient, and
unreliable process. Efforts to replace or supplement traditional evaluation models with open …

This study evaluates single-cell indicators of glutamate transport in sulforhodamine 101-
positive astrocytes of Q175 mice, a knock-in model of Huntington's disease (HD). Transport …

Over the past decades, our view of astrocytes has switched from passive support cells to
active processing elements in the brain. The current view is that astrocytes shape neuronal …

The human visual system is a complex and interconnected network comprising billions of
neurons. It plays an essential role in translating environmental light stimuli into information …

Previously, we showed that the overexpression of ORAI1 calcium channel in neurons of
murine brain led to spontaneous occurrence of seizure-like events in aged animals of …