The mammalian ABL1 gene encodes the ubiquitously expressed nonreceptor tyrosine
kinase ABL. In response to growth factors, cytokines, cell adhesion, DNA damage, oxidative …

Nuclear export is an essential eukaryotic activity. It proceeds through nuclear pore
complexes (NPCs) and is mediated by soluble receptors that shuttle between nucleus and …

CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs
from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth …

Much of what is known about mammalian cell regulation has been achieved with the aid of
transiently transfected cells. However, overexpression can violate balanced gene dosage …

Cells undergo apoptosis upon exposure to severe DNA damage stress. Under this
condition, p73 is phosphorylated and activated by c-Abl. The transcription coactivator Yap1 …

Classic nuclear export signals (NESs) confer CRM1-dependent nuclear export. Here we
present crystal structures of the RanGTP− CRM1 complex alone and bound to the prototypic …

Abl kinases are prototypic cytoplasmic tyrosine kinases and are involved in a variety of
chromosomal aberrations in different cancers. This causes the expression of Abl fusion …

We compiled> 200 nuclear export signal (NES)–containing CRM1 cargoes in a database
named NESdb. We analyzed the sequences and three-dimensional structures of natural …

In addition to its long-studied presence in the cytoplasm, actin is also found in the nuclei of
eukaryotic cells. The function and form (monomer, filament, or noncanonical oligomer) of …

The tyrosine kinase Bcr-Abl causes chronic myeloid leukemia and is the cognate target of
tyrosine kinase inhibitors like imatinib. We have charted the protein–protein interaction …