Precise pre-mRNA splicing, essential for appropriate protein translation, depends on the
presence of consensus “cis” sequences that define exon-intron boundaries and regulatory …

Synonymous codon changes, which do not alter protein sequence, were previously thought
to have no functional consequence. Although this concept has been overturned in recent …

Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

Almost all protein-coding genes are spliced and their majority is alternatively spliced.
Alternative splicing is a key element in eukaryotic gene expression that increases the coding …

Ninety‐four percent of human genes are discontinuous, such that segments expressed as
mRNA are contained within exons and separated by intervening segments, called introns …

Alternative splicing creates transcriptome diversification, possibly leading to speciation. A
large fraction of the protein-coding genes of multicellular organisms are alternatively spliced …

During evolution segments of homeothermic genomes underwent a GC content increase.
Our analyses reveal that two exon-intron architectures have evolved from an ancestral state …

We have collected over half a million splice sites from five species—Homo sapiens, Mus
musculus, Drosophila melanogaster, Caenorhabditis elegans and Arabidopsis thaliana …

Splice site selection is fundamental to pre-mRNA splicing and the expansion of genomic
coding potential. 5′ Splice sites (5′ ss) are the critical elements at the 5′ end of introns …

To gain global insights into the role of the well-known repressive splicing regulator PTB, we
analyzed the consequences of PTB knockdown in HeLa cells using high-density …