Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Intestinal immune cell trafficking has been identified as a central event in the pathogenesis
of inflammatory bowel diseases (IBD). Intensive research on different aspects of the immune …

Inducible regulatory T (iTreg) cells play a crucial role in immune suppression and are
important for the maintenance of immune homeostasis. Mounting evidence has …

It remains unknown what causes inflammatory bowel disease (IBD), including signaling
networks perpetuating chronic gastrointestinal inflammation in Crohn's disease (CD) and …

Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder that is difficult
to cure and characterized by periods of relapse. To face the challenges of limited treatment …

Background Restoring immune homeostasis by targeting the Th17/Treg response is a
potentially valuable therapeutic strategy for ulcerative colitis (UC). Astragaloside IV (AS-Ⅳ) …

The imbalance between Th17 and Treg cells substantially contributes to the intestinal
immune disturbance and subsequent tissue injury in ulcerative colitis. The triterpenoid-rich …

Distinct integrin activation pathways for effector and regulatory T cell trafficking and function |
Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …

Background HIV infection promotes the expansion of immunosuppressive regulatory T-cells
(Tregs), contributing to immune dysfunction, tissue fibrosis and disease progression. Early …

Abstract Background Chinese herbal medicine Qing-Chang-Hua-Shi granule (QCHS) is
widely used to treat ulcerative colitis in China. However, the molecular mechanisms of …