70-year legacy of the Framingham Heart Study
Abstract The Framingham Heart Study (FHS) was established in 1948 to improve
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …
[HTML][HTML] Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
KL Pennington, MM DeAngelis - Eye and vision, 2016 - Springer
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …
A decade of genome-wide association studies for coronary artery disease: the challenges ahead
J Erdmann, T Kessler, L Munoz Venegas… - Cardiovascular …, 2018 - academic.oup.com
In this review, we summarize current knowledge on the genetics of coronary artery disease,
based on 10 years of genome-wide association studies. The discoveries began with …
based on 10 years of genome-wide association studies. The discoveries began with …
Genomic prediction of coronary heart disease
Aims Genetics plays an important role in coronary heart disease (CHD) but the clinical utility
of genomic risk scores (GRSs) relative to clinical risk scores, such as the Framingham Risk …
of genomic risk scores (GRSs) relative to clinical risk scores, such as the Framingham Risk …
[HTML][HTML] Predictive utility of polygenic risk scores for coronary heart disease in three major racial and ethnic groups
Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from
mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic …
mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic …
[HTML][HTML] QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function
X Chen, Y Liu, C Xu, L Ba, Z Liu, X Li, J Huang… - Nature …, 2021 - nature.com
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a
well-known regulator of pre-mRNA alternative splicing and is associated with several …
well-known regulator of pre-mRNA alternative splicing and is associated with several …
Emerging roles for RNA-binding proteins as effectors and regulators of cardiovascular disease
RG de Bruin, TJ Rabelink… - European heart …, 2017 - academic.oup.com
The cardiovascular system comprises multiple cell types that possess the capacity to
modulate their phenotype in response to acute or chronic injury. Transcriptional and post …
modulate their phenotype in response to acute or chronic injury. Transcriptional and post …
[HTML][HTML] Integrated genetic and epigenetic prediction of coronary heart disease in the Framingham Heart Study
An improved method for detecting coronary heart disease (CHD) could have substantial
clinical impact. Building on the idea that systemic effects of CHD risk factors are a …
clinical impact. Building on the idea that systemic effects of CHD risk factors are a …
[HTML][HTML] The application of big data to cardiovascular disease: paths to precision medicine
JA Leopold, BA Maron, J Loscalzo - The Journal of clinical …, 2020 - Am Soc Clin Investig
Advanced phenotyping of cardiovascular diseases has evolved with the application of high-
resolution omics screening to populations enrolled in large-scale observational and clinical …
resolution omics screening to populations enrolled in large-scale observational and clinical …
[HTML][HTML] Genome-wide association studies on coronary artery disease: A systematic review and implications for populations of different ancestries
Background Cardiovascular diseases are some of the leading causes of death worldwide,
with coronary artery disease leading as one of the primary causes of mortality in both the …
with coronary artery disease leading as one of the primary causes of mortality in both the …