Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To
determine the fate of aneuploid cells and the developmental potential of mosaic embryos …

Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …

Despite a conserved role for histones as general DNA packaging agents, it is now clear that
another key function of these proteins is to confer variations in chromatin structure to ensure …

Every eukaryotic chromosome has a centromere, the locus responsible for poleward
movement at mitosis and meiosis. Although conventional loci are specified by their DNA …

The centromere is a chromosomal locus that ensures delivery of one copy of each
chromosome to each daughter at cell division. Efforts to understand the nature and …

In eukaryotes, accurate chromosome segregation during mitosis and meiosis is coordinated
by kinetochores, which are unique chromosomal sites for microtubule attachment …