Current status of the new antiepileptic drugs in chronic pain

HS Sidhu, A Sadhotra - Frontiers in pharmacology, 2016 - frontiersin.org
Antiepileptic drugs (AEDs) are extensively used worldwide to treat a wide range of disorders
other than epilepsy, such as neuropathic pain, migraine, and bipolar disorder. Due to this …

Levetiracetam as an antiepileptic, neuroprotective, and hyperalgesic drug

JL Cortes-Altamirano, A Olmos-Hernández… - Neurology …, 2016 - journals.lww.com
The main purpose of this review was to expound upon the mechanism of action of
Levetiracetam (LEV) as an antiepileptic, neuroprotective, and hyperalgesic drug. LEV is a …

Levetiracetam in spinal cord injury pain: a randomized controlled trial

NB Finnerup, J Grydehøj, J Bing, IL Johannesen… - Spinal cord, 2009 - nature.com
Study design: A randomized, double-blind, placebo-controlled, crossover, multicenter trial. A
1-week baseline period was followed by two treatment periods of 5 weeks duration with …

Levetiracetam in patients with central neuropathic post‐stroke pain–a randomized, double‐blind, placebo‐controlled trial

GJ Jungehulsing, H Israel, N Safar… - European Journal of …, 2013 - Wiley Online Library
Background and purpose Central post‐stroke pain (CPSP) is a severe chronic neuropathic
pain condition defined as a spontaneous pain or allodynia corresponding to a vascular …

Effect of levetiracetam versus gabapentin on peripheral neuropathy and sciatic degeneration in streptozotocin-diabetic mice: Influence on spinal microglia and …

HM Reda, SA Zaitone, YM Moustafa - European journal of pharmacology, 2016 - Elsevier
Peripheral diabetic neuropathy develops in diabetic patients. The current study tested the
antiallodynic and antihyperalgesic effects of the anticonvulsant drug, levetiracetam …

Neuroprotective effects of chronic administration of levetiracetam in a rat model of diabetic neuropathy

O Erbaş, F Oltulu, M Yılmaz, A Yavaşoğlu… - Diabetes research and …, 2016 - Elsevier
Objective Diabetic neuropathy (DNP) is a frequent and serious complication of diabetes
mellitus (DM) that leads to progressive and length-dependent loss of peripheral nerve …

Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy

A Micov, M Tomić, U Pecikoza, N Ugrešić… - Pharmacological …, 2015 - Elsevier
Painful diabetic neuropathy is difficult to treat. Single analgesics often have insufficient
efficacy and poor tolerability. Combination therapy may therefore be of particular benefit …

An observational trial to investigate the efficacy and tolerability of levetiracetam in trigeminal neuralgia

DD Mitsikostas, GV Pantes… - … : The Journal of …, 2010 - Wiley Online Library
Objective.—To explore the efficacy and tolerability of levetiracetam in medical treatment of
trigeminal neuralgia. Background.—Antiepileptic drugs (AEDs) are considered as first‐line …

A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin

L Di Cesare Mannelli, M Maresca, L Micheli… - Cancer Chemotherapy …, 2017 - Springer
Background and aim The FOLFOX family of chemotherapy regimens are hampered by the
development of a painful neuropathy. Current clinical treatments are inadequate, and …

Analgesic effects of mad honey (grayanotoxin) in mice models of acute pain and painful diabetic neuropathy

A Gunduz, I Eraydin, S Turkmen… - Human & …, 2014 - journals.sagepub.com
Objectives: The aim of this experimental study was to investigate the effects of mad honey
(grayanotoxin, GTX), used in complementary medicine for a variety of purposes besides …