Although deep brain stimulation (DBS) is an established treatment choice for Parkinson's
disease (PD), essential tremor and movement disorders, its effectiveness for the …

Background Current practice for selecting pharmacological and non-pharmacological
antidepressant treatments has yielded low response and remission rates in Major …

Background Deep brain stimulation is increasingly being used for treatment‐resistant
depression. Blinded, randomized controlled trials of active versus sham treatment have …

Objective: Deep brain stimulation (DBS) has shown promising outcomes as new therapeutic
opportunities for patients with treatment-resistant depression (TRD) who do not respond …

Background: The electrical parameters used for deep brain stimulation (DBS) in movement
disorders have been relatively well studied, however for the newer indications of DBS for …

Background Deep brain stimulation (DBS) has been applied in treatment-resistant
depression (TRD) as a putative intervention targeting different brain regions. However, the …

Major depressive disorder (MDD) affects approximately 4.4% of the world's population. One
third of MDD patients do not respond to routine psychotherapeutic and pharmacotherapeutic …

Objective To characterize the functional connectivity (FC) of target brain regions for deep
brain stimulation (DBS) in patients with treatment-resistant depression (TRD), and to …

Background Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) is an
experimental approach in treatment-resistant depression (TRD). Short-term results of …

The lateral habenula plays a central role in reward and punishment processing and has
been suggested to drive the cardinal symptom of anhedonia in depression. This hypothesis …