The role of toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation

LJ McGhan, DE Jaroszewski - Injury, 2012 - Elsevier
Haemorrhagic shock and resuscitation (HS/R) following major trauma results in a global
ischaemia and reperfusion injury that may lead to multiple organ dysfunction syndrome …

Hypoxia potentiates palmitate-induced pro-inflammatory activation of primary human macrophages

RG Snodgrass, M Boß, E Zezina, A Weigert… - Journal of biological …, 2016 - ASBMB
Pro-inflammatory cytokines secreted by adipose tissue macrophages (ATMs) contribute to
chronic low-grade inflammation and obesity-induced insulin resistance. Recent studies have …

Preconditioned hyperbaric oxygenation protects the liver against ischemia-reperfusion injury in rats

SY Yu, JH Chiu, SD Yang, HY Yu, CC Hsieh… - Journal of Surgical …, 2005 - Elsevier
Hyperbaric oxygen (HBO) therapy is an effective adjunct in treating ischemia-reperfusion
(I/R) injury of brain, small intestine, testis, and crushing extremities. This study was designed …

Effects of N-acetylcysteine on myocardial ischemia–reperfusion injury in bypass surgery

G Orhan, N Yapici, M Yuksel, M Sargin, Ş Şenay… - Heart and vessels, 2006 - Springer
Myocardial ischemia–reperfusion injury may complicate coronary artery bypass grafting
(CABG) operations. N-Acertylcysteine (NAC) had antioxidant and microcirculatory effects …

Beneficial effects of rutin and l-arginine coadministration in a rat model of liver ischemia-reperfusion injury

R Acquaviva, R Lanteri, G Li Destri… - American Journal …, 2009 - journals.physiology.org
Reperfusion following liver ischemia results in oxidative stress leading to liver injury. The
aim of this study was to investigate the combined effects of two antioxidant agents, rutin and l …

Nitrosative and oxidative stresses contribute to post-ischemic liver injury following severe hemorrhagic shock: the role of hypoxemic resuscitation

EE Douzinas, O Livaditi, MK Tasoulis, P Prigouris… - PLoS …, 2012 - journals.plos.org
Purpose Hemorrhagic shock and resuscitation is frequently associated with liver ischemia-
reperfusion injury. The aim of the study was to investigate whether hypoxemic resuscitation …

N-Acetylcysteine Reduced Ischemia and Reperfusion Damage Associated with Steatohepatitis in Mice

N Chaves Cayuela, M Kiyomi Koike… - International Journal of …, 2020 - mdpi.com
N-acetylcysteine (NAC) is a pharmacological alternative with great potential for reducing the
deleterious effects of surgical procedures on patients with steatohepatitis. We evaluated the …

Pretreatment with Pentoxifylline and N-Acetylcysteine in Liver Ischemia Reperfusion-Induced Renal Injury

B Seifi, M Kadkhodaee, F Delavari, S Mikaeili… - Renal …, 2012 - Taylor & Francis
Background and Aims: Acute hepatic injury causes systematic inflammatory responses
which may finally lead to functional disturbances in remote organs. In this study, the effects …

Effect of N-acetylcysteine in hearts of rats submitted to controlled hemorrhagic shock

LD Oliveira Filho, KR Saad, PF Saad… - Revista Brasileira de …, 2015 - SciELO Brasil
Introduction: Pharmacological therapy is a strategy for the prevention of complications
associated with ischemia and reperfusion injury that occurs after volume replacement in the …

Effect of N-acetylcysteine in liver ischemia-reperfusion injury after 30% hepatectomy in mice

EJS Lee, SM Silva, MJ Simões… - Acta Cirúrgica …, 2012 - SciELO Brasil
PURPOSE: Evaluate the effect of N-acetylcysteine in liver remnant after hepatectomy
associated to ischemia-reperfusion injury in mice. METHODS: Male adult BALB/c mice …