Identification of neoantigens for individualized therapeutic cancer vaccines
Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …
recognized by autologous T cells in the host. As neoepitopes are not subject to central …
[HTML][HTML] Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
[HTML][HTML] Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma
Z Yang, C Yan, J Ma, P Peng, X Ren, S Cai, X Shen… - Nature …, 2023 - nature.com
Enhanced glycolysis and accumulation of lactate is a common feature in various types of
cancer. Intracellular lactate drives a recently described type of posttranslational modification …
cancer. Intracellular lactate drives a recently described type of posttranslational modification …
[HTML][HTML] A novel cuproptosis-related prognostic gene signature and validation of differential expression in clear cell renal cell carcinoma
Z Bian, R Fan, L Xie - Genes, 2022 - mdpi.com
Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell
carcinoma, which is characterized by metabolic reprogramming. Cuproptosis, a novel form …
carcinoma, which is characterized by metabolic reprogramming. Cuproptosis, a novel form …
[HTML][HTML] The evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide. Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 …
[HTML][HTML] Non-viral precision T cell receptor replacement for personalized cell therapy
T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells,–.
Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision …
Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision …
[HTML][HTML] Trastuzumab deruxtecan in metastatic breast cancer with variable HER2 expression: the phase 2 DAISY trial
The mechanisms of action of and resistance to trastuzumab deruxtecan (T-DXd), an anti-
HER2–drug conjugate for breast cancer treatment, remain unclear. The phase 2 DAISY trial …
HER2–drug conjugate for breast cancer treatment, remain unclear. The phase 2 DAISY trial …
Life histories of myeloproliferative neoplasms inferred from phylogenies
N Williams, J Lee, E Mitchell, L Moore, EJ Baxter… - Nature, 2022 - nature.com
Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …
A clinically applicable integrative molecular classification of meningiomas
Meningiomas are the most common primary intracranial tumour in adults. Patients with
symptoms are generally treated with surgery as there are no effective medical therapies. The …
symptoms are generally treated with surgery as there are no effective medical therapies. The …