Engineered, light-sensitive protein switches are used to interrogate a broad variety of
biological processes. These switches are typically constructed by genetically fusing naturally …

Protein engineering is important for creating novel variants from natural proteins, enabling a
wide range of applications. Approaches such as rational design and directed evolution are …

Natural or engineered peptides serve important biological functions. A general approach to
achieve chemical-dependent activation of short peptides will be valuable for spatial and …

We present time‐resolved Gd− Gd electron paramagnetic resonance (TiGGER) at 240 GHz
for tracking inter‐residue distances during a protein's mechanical cycle in the solution state …

Neuromodulators play crucial roles in regulating neuronal activity and affecting various
aspects of brain functions, including learning, memory, cognitive functions, emotional states …

Circular permutation (CP) is a technique by which the primary sequence of a protein is
rearranged to create new termini. The connectivity of the protein is altered but the overall …

Photo switchable proteins enable specific molecular events occurring in complex biological
settings to be probed in a rapid and reversible fashion. Recent progress in the development …

Flavin‐based fluorescent proteins are oxygen‐independent reporters that hold great
promise for imaging anaerobic and hypoxic biological systems. In this study, we explored …

The protein kinase mechanistic target of rapamycin complex 1 (mTORC1) is one of the
primary triggers for initiating cap-dependent translation. Amongst its functions, mTORC1 …

Optogenetic techniques offer a high spatiotemporal resolution to manipulate cellular activity.
For instance, Channelrhodopsin-2 with global light illumination is the most widely used to …