During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

The ability to specifically upregulate genes in vivo holds great therapeutic promise. Here we
show that inhibition or degradation of natural antisense transcripts (NATs) by single …

Small double-strand RNA (dsRNA) molecules can activate endogenous genes via an RNA-
based promoter targeting mechanism. RNA activation (RNAa) is an evolutionarily conserved …

The brain‐derived neurotrophic factor (BDNF) gene is expressed in differentiating and post‐
mitotic neurons of the zebrafish embryo, where it has been implicated in Huntington's …

Neurodevelopmental disorders are a group of conditions that arises from impairments of the
central nervous system during its development. The causes of the various disorders are …

Dendrites, axons, and synapses are dynamic during circuit development; however, changes
in microcircuit connections as branches stabilize have not been directly demonstrated. By …

Homeostatic plasticity plays important role in regulating synaptic and intrinsic neuronal
function to stabilize output following perturbations to circuit activity. In glaucoma, a …

Docosahexaenoic acid (DHA, 22: 6n-3) is an essential component of the nervous system,
and maternal n-3 polyunsaturated fatty acids (PUFAs) are an important source for brain …

The roles of myelin in maintaining axonal integrity and action potential (AP) propagation are
well established, but its role in synapse maintenance and neurotransmission remains …

Brain-derived neurotrophic factor (BDNF) is an important regulator of circuit development,
neuronal survival, and plasticity throughout the nervous system. In the visual system, BDNF …