Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

Abstract The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR;
however, its function was unknown. Subsequent studies suggest that the MC4R might be …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …

Our understanding of the physiological systems that regulate food intake and body weight
has increased immensely over the past decade. Brain centres, including the hypothalamus …

Abstract The melanocortin 4 receptor (MC4‐R) plays a pivotal role in maintaining energy
homeostasis in rodents and humans. For example, MC4‐R deletion or mutation results in …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Mutations in the human melanocortin (MC) 4 receptor have been associated with obesity,
which underscores the relevance of this receptor as a drug target to treat obesity. Infusion of …

Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades …

The capacity to adjust energy intake in response to changing energy requirements is a
defining feature of energy homeostasis. Despite the identification of leptin as a key mediator …

Both central α-melanocyte-stimulating hormone and corticotropin-releasing hormone (CRH)
have been implicated in feeding and neuroendocrine mechanisms. The anatomical overlap …