Endocannabinoid system components as potential biomarkers in psychiatry

F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2020 - frontiersin.org
The high heterogeneity of psychiatric disorders leads to a lack of diagnostic precision.
Therefore, the search of biomarkers is a fundamental aspect in psychiatry to reach a more …

Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation

SB Raut, PA Marathe, L van Eijk, R Eri… - Pharmacology & …, 2022 - Elsevier
Post-traumatic stress disorder (PTSD), characterized by abnormally persistent and
distressing memories, is a chronic debilitating condition in need of new treatment options …

Cannabinoid regulation of fear and anxiety: an update

EP Papagianni, CW Stevenson - Current psychiatry reports, 2019 - Springer
Abstract Purpose of Review Anxiety-and trauma-related disorders are prevalent and
debilitating mental illnesses associated with a significant socioeconomic burden. Current …

Circulating endocannabinoids and genetic polymorphisms as predictors of posttraumatic stress disorder symptom severity: heterogeneity in a community-based cohort

TA deRoon-Cassini, CL Bergner, SA Chesney… - Translational …, 2022 - nature.com
The endocannabinoid signaling system (ECSS) regulates fear and anxiety. While ECSS
hypoactivity can contribute to symptoms of established post-traumatic stress disorder …

Meet your stress management professionals: the endocannabinoids

TA deRoon-Cassini, TM Stollenwerk, M Beatka… - Trends in molecular …, 2020 - cell.com
The endocannabinoid signaling system (ECSS) is altered by exposure to stress and
mediates and modulates the effects of stress on the brain. Considerable preclinical data …

Understanding the dynamic and destiny of memories

L de Oliveira Alvares, FH Do-Monte - Neuroscience & Biobehavioral …, 2021 - Elsevier
Memory formation enables the retention of life experiences overtime. Based on previously
acquired information, organisms can anticipate future events and adjust their behaviors to …

The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial

MP Paulus, MB Stein, AN Simmons… - …, 2021 - nature.com
Acute pharmacological inhibition of the anandamide-degrading enzyme, fatty acid amide
hydrolase (FAAH), prolongs the regulatory effects of endocannabinoids and reverses the …

Cannabinoid interventions for PTSD: Where to next?

LJ Ney, A Matthews, R Bruno… - Progress in Neuro …, 2019 - Elsevier
Cannabinoids are a promising method for pharmacological treatment of post-traumatic
stress disorder (PTSD). Despite considerable research devoted to the effect of cannabinoid …

Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats

S Schiavi, A Manduca, E Carbone, V Buzzelli… - …, 2023 - nature.com
Autism spectrum disorder (ASD) has a multifactorial etiology. Major efforts are underway to
understand the neurobiological bases of ASD and to develop efficacious treatment …

Cannabinoids as therapeutics for PTSD

B Sbarski, I Akirav - Pharmacology & therapeutics, 2020 - Elsevier
Post-traumatic stress disorder (PTSD) is a complex disorder that involves dysregulation of
multiple neurobiological systems. The traumatic stressor plays a causal role in producing …