To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

RNAs are central to all gene expression through the control of protein synthesis. Four major
nucleosides, adenosine, guanosine, cytidine and uridine, compose RNAs and provide …

Classical molecular dynamics (MD) simulations are useful for characterizing the structure
and dynamics of biological macromolecules, ultimately, resulting in elucidation of biological …

Bacterial and eukaryotic transfer RNAs have been shown to contain hypermodified
adenosine, 2-methylthio-N 6-threonylcarbamoyladenosine, at position 37 (A 37) adjacent to …

Human tRNALys3UUU (htRNALys3UUU) decodes the lysine codons AAA and AAG during
translation and also plays a crucial role as the primer for HIV-1 (human immunodeficiency …

More than 100 naturally occurring modified nucleotides have been found in RNA molecules,
in particular in tRNAs. We have determined molecular mechanics force field parameters …

A remarkable number of neurodevelopmental disorders have been linked to defects in tRNA
modifications. These discoveries place tRNA modifications in the spotlight as critical …

Nucleic acids are polyanionic molecules that were historically considered to be solely
surrounded by a shell of water molecules and a neutralizing cloud of monovalent and …

Ribonucleotide modifications perform a wide variety of roles in synthesis, turnover and
functionality of tRNA molecules. The presence of particular chemical moieties can refine the …

Ribonucleic acid (RNA) molecules can adopt a variety of secondary and tertiary structures in
solution, with stem-loops being one of the more common motifs. Here, we present a …