The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Many gene defects are relatively easy to identify experimentally, but obtaining information
about the effects of sequence variations and elucidation of the detailed molecular …

In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that
assembles at the core promoter is required for the opening of the duplex DNA and …

The G protein‐coupled receptor (GPCR) Proteolysis Site (GPS) of cell‐adhesion GPCRs
and polycystic kidney disease (PKD) proteins constitutes a highly conserved autoproteolysis …

Stu2p/XMAP215/Dis1 family proteins are evolutionarily conserved regulatory factors that use
αβ-tubulin–interacting tumor overexpressed gene (TOG) domains to catalyze fast …

Small molecules containing the N-nitroso group, such as the bacterial natural product
streptozotocin, are prominent carcinogens, and important cancer chemotherapeutics …

Mutations in the X-linked MECP2 cause Rett syndrome, a devastating neurological disorder
typified by a period of apparently normal development followed by loss of cognitive and …

Despite extensive efforts, half of patients with rare movement disorders such as hereditary
spastic paraplegias and cerebellar ataxias remain genetically unexplained, implicating …

Bitter taste is essential for survival, as it protects against consuming poisonous compounds,
which are often bitter. Bitter taste perception is mediated by bitter taste receptors (TAS2Rs) …

Prochlorococcus, an abundant phototroph in the oceans, are infected by members of three
families of viruses: myo‐, podo‐and siphoviruses. Genomes of myo‐and podoviruses …