Salan vs. salen metal complexes in catalysis and medicinal applications: Virtues and pitfalls
Salen complexes are widely employed in catalysis and biomedical science and chiral salen
complexes are among the most important catalysts for asymmetric synthesis. Their reduced …
complexes are among the most important catalysts for asymmetric synthesis. Their reduced …
Using X-ray diffraction techniques for biomimetic drug development, formulation, and polymorphic characterization
Drug development is a decades-long, multibillion dollar investment that often limits itself. To
decrease the time to drug approval, efforts are focused on drug targets and drug formulation …
decrease the time to drug approval, efforts are focused on drug targets and drug formulation …
LVVO-Ethyl Maltol-Based Metallodrugs (L2– = Tridentate ONO Ligands): Hydrophobicity, Hydrolytic Stability, and Cytotoxicity via ROS-Mediated Apoptosis
Four new oxidovanadium [VVOL1–4 (ema)] complexes (1–4) have been synthesized using
tridentate binegative ONO donor ligands H2L1–4 [H2L1:(E)-N′-(2-hydroxybenzylidene) …
tridentate binegative ONO donor ligands H2L1–4 [H2L1:(E)-N′-(2-hydroxybenzylidene) …
Hydrolytically Stable and Cytotoxic [ONON]2Ti(IV)-Type Octahedral Complexes
A Pedko, E Rubanovich, EY Tshuva… - Inorganic Chemistry, 2022 - ACS Publications
A new family of titanium (IV) complexes based on [ONON] diaminobis (phenolato) ligands
with Me, Br, Cl, and F ortho substitutions was synthesized and characterized. X-ray …
with Me, Br, Cl, and F ortho substitutions was synthesized and characterized. X-ray …
Expanding the therapeutic potential of the iron chelator deferasirox in the development of aqueous stable Ti (IV) anticancer complexes
SA Loza-Rosas, AM Vázquez-Salgado… - Inorganic …, 2017 - ACS Publications
The recent X-ray structure of titanium (IV)-bound human serum transferrin (STf) exhibiting
citrate as a synergistic anion reveals a difference in Ti (IV) coordination versus iron (III), the …
citrate as a synergistic anion reveals a difference in Ti (IV) coordination versus iron (III), the …
Specific design of titanium (IV) phenolato chelates yields stable and accessible, effective and selective anticancer agents
Octahedral titanium (IV) complexes of phenolato hexadentate ligands were developed and
showed very high stability for days in water solutions. In vitro cytotoxicity studies showed …
showed very high stability for days in water solutions. In vitro cytotoxicity studies showed …
High antitumor activity of highly resistant salan-titanium (IV) complexes in nanoparticles: an identified active species.
S Meker, K Margulis-Goshen, E Weiss… - … (International ed. in …, 2012 - europepmc.org
A nanoformulated trinuclear hydrolysis product of a bis (alkoxo) salan-Ti (IV) complex shows
high antitumor activity, which identifies it as an active species in cells. Additional highly …
high antitumor activity, which identifies it as an active species in cells. Additional highly …
A ubiquitous metal, difficult to track: towards an understanding of the regulation of titanium(iv) in humans
Despite the ubiquitous nature of titanium (iv) and several examples of its beneficial behavior
in different organisms, the metal remains underappreciated in biology. There is little …
in different organisms, the metal remains underappreciated in biology. There is little …
C1-Symmetrical Titanium(IV) Complexes of Salan Ligands with Differently Substituted Aromatic Rings: Enhanced Cytotoxic Activity
H Glasner, EY Tshuva - Inorganic Chemistry, 2014 - ACS Publications
Diaminobis (phenolato)(“salan”) titanium (IV) complexes of differently substituted aromatic
rings were synthesized, and their hydrolytic stability and cytotoxicity were analyzed and …
rings were synthesized, and their hydrolytic stability and cytotoxicity were analyzed and …
Anti-tumoral titanium (IV) complexes stabilized with phenolato ligands and structure-activity relationship
T Zhao, P Wang, X Zhang, N Liu… - Current Topics in …, 2023 - ingentaconnect.com
Titanocene dichloride and budotitane have opened a new chapter in medicinal chemistry of
titanium (IV) complexes being novel non-platinum antitumor metallic agents. Numerous …
titanium (IV) complexes being novel non-platinum antitumor metallic agents. Numerous …