Disruption of redox homeostasis is a key phenotype of many pathological conditions.
Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as …

Here we have outlined the recent (2011–2022) developments in the synthesis of modified
indomethacin-based analogues for the selective inhibition of COX-2 and then highlighted …

The increasing number of patients suffering from chronic obstructive pulmonary disease
(COPD) represents a major and increasing health problem. Therefore, novel therapeutic …

Herin we report the design, synthesis, full characterization and biological investigation of
new 15-LOX/COX dual inhibitors based on 1, 3-thiazolidin-4-one (15-lipoxygenase …

Inflammation is favorable in most cases, because it is a kind of body defensive response to
external stimuli; sometimes, inflammation is also harmful, such as attacks on the body's own …

Chronic obstructive pulmonary disease (COPD) constitutes a major health burden. Studying
underlying molecular mechanisms could lead to new therapeutic targets. Macrophages are …

Abstract Ethnopharmacological relevance The Northeastern state of India is known for its
remarkable biodiversity and untapped medicinal resources. Jussiaea repens L., commonly …

Lysine acetylations are reversible posttranslational modifications of histone and non-histone
proteins that play important regulatory roles in signal transduction cascades and gene …

Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …

A new series of thieno [2, 3-d] pyrimidine derivatives 4, 5, 6a-o, and 11 was designed and
synthesized starting from cyclohexanone under Gewald condition with the aim to develop …