The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Cardiac hypertrophy is an adaptive response to physiological and pathological overload. In
response to the overload, individual cardiac myocytes become mechanically stretched and …

The heart is capable of responding to stressful situations by increasing muscle mass, which
is broadly defined as cardiac hypertrophy. This phenomenon minimizes ventricular wall …

Heart failure (HF) is a leading cause of morbidity and mortality in the United States. Despite
a number of important therapeutic advances for the treatment of symptomatic HF, 1 the …

Endoplasmic reticulum stress is an evolutionarily conserved cell stress response associated
with numerous diseases, including cardiac hypertrophy and heart failure. The major …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

Postnatal growth of the heart is primarily achieved through hypertrophy of individual
myocytes. Cardiac growth observed in athletes represents adaptive or physiological …

Idiopathic dilated cardiomyopathy (IDC) is characterized by left ventricular (LV) enlargement
with systolic dysfunction, other causes excluded. When inherited, it represents familial …

There is an association between obesity and heart failure associated with LV dysfunction.
Adiponectin is an adipocyte-derived hormone that is downregulated in obesity. Here, we …

Background Exosomes are small extracellular vesicles that function as intercellular
messengers and effectors. Exosomal cargo contains regulatory small molecules, including …