Designing antimicrobial peptides: form follows function

CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

Antifungal defensins and their role in plant defense

AF Lacerda, ÉAR Vasconcelos, PB Pelegrini… - Frontiers in …, 2014 - frontiersin.org
Since the beginning of the 90s lots of cationic plant, cysteine-rich antimicrobial peptides
(AMP) have been studied. However, only coined the term “plant defensin,” after comparison …

Plant thaumatin-like proteins: function, evolution and biotechnological applications

C de Jesús-Pires, JRC Ferreira-Neto… - Current Protein and …, 2020 - ingentaconnect.com
Thaumatin-like proteins (TLPs) are a highly complex protein family associated with host
defense and developmental processes in plants, animals, and fungi. They are highly diverse …

Plant antimicrobial peptides: state of the art, in silico prediction and perspectives in the omics era

CA Santos-Silva, L Zupin… - … and Biology Insights, 2020 - journals.sagepub.com
Even before the perception or interaction with pathogens, plants rely on constitutively
guardian molecules, often specific to tissue or stage, with further expression after contact …

Future of antimicrobial peptides derived from plants in food application–A focus on synthetic peptides

LN Shwaiki, KM Lynch, EK Arendt - Trends in Food Science & Technology, 2021 - Elsevier
Background Food spoilage is caused by the undesirable growth of spoilage microorganisms
in food products. This spoilage can lead to the global loss and waste of food. It is estimated …

Plant defensins and defensin-like peptides-biological activities and biotechnological applications

A de Oliveira Carvalho… - Current pharmaceutical …, 2011 - ingentaconnect.com
Plant defensins are cationic peptides that are ubiquitous within the plant kingdom and
belong to a large superfamily of antimicrobial peptides found in several organisms …

The membrane interactions of antimicrobial peptides revealed by solid-state NMR spectroscopy

B Bechinger, ES Salnikov - Chemistry and physics of lipids, 2012 - Elsevier
Solid-state NMR spectroscopic techniques provide valuable information about the structure,
dynamics and topology of membrane-inserted polypeptides. In particular antimicrobial …

The effect of amidation on the behaviour of antimicrobial peptides

M Mura, J Wang, Y Zhou, M Pinna… - European Biophysics …, 2016 - Springer
Abstract Aurein 2.6-COOH and aurein 3.1-COOH were studied along with their naturally
occurring C-terminally amidated analogues. Circular dichroism (CD) and molecular dynamic …

Comparative analysis of the bacterial membrane disruption effect of two natural plant antimicrobial peptides

A Farkas, G Maróti, A Kereszt, É Kondorosi - Frontiers in microbiology, 2017 - frontiersin.org
In the Medicago truncatula genome about 700 genes code for nodule-specific cysteine-rich
(NCR) small peptides that are expressed in the symbiotic organ, the root nodule, where they …

Amino acid–derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

A Parthasarathy, EJ Borrego, MA Savka… - Journal of Biological …, 2021 - ASBMB
For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …