Retinal microglia: just bystander or target for therapy?
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
[HTML][HTML] Neuroprotective strategies for retinal disease
Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and
glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of …
glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of …
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
GR Howell, DG Macalinao, GL Sousa… - The Journal of …, 2011 - Am Soc Clin Investig
Glaucoma is one of the most common neurodegenerative diseases. Despite this, the earliest
stages of this complex disease are still unclear. This study was specifically designed to …
stages of this complex disease are still unclear. This study was specifically designed to …
Critical pathogenic events underlying progression of neurodegeneration in glaucoma
DJ Calkins - Progress in retinal and eye research, 2012 - Elsevier
Glaucoma is a common optic neuropathy with a complex etiology often linked to sensitivity to
intraocular pressure. Though the precise mechanisms that mediate or transduce this …
intraocular pressure. Though the precise mechanisms that mediate or transduce this …
The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice
RM Sappington, BJ Carlson, SD Crish… - … & visual science, 2010 - iovs.arvojournals.org
Purpose.: Elevated intraocular pressure (IOP) is an important risk factor for glaucoma.
Animal models often involve techniques for IOP elevation that are surgically invasive. Here …
Animal models often involve techniques for IOP elevation that are surgically invasive. Here …
Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma
L Della Santina, DM Inman, CB Lupien… - Journal of …, 2013 - Soc Neuroscience
Intraocular pressure (IOP) elevation is a principal risk factor for glaucoma. Using a
microbead injection technique to chronically raise IOP for 15 or 30 d in mice, we identified …
microbead injection technique to chronically raise IOP for 15 or 30 d in mice, we identified …
Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy
Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …
Animal models of glaucoma
R A. Bouhenni, J Dunmire, A Sewell… - BioMed Research …, 2012 - Wiley Online Library
Glaucoma is a heterogeneous group of disorders that progressively lead to blindness due to
loss of retinal ganglion cells and damage to the optic nerve. It is a leading cause of …
loss of retinal ganglion cells and damage to the optic nerve. It is a leading cause of …
Etanercept, a widely used inhibitor of tumor necrosis factor-α (TNF-α), prevents retinal ganglion cell loss in a rat model of glaucoma
Background Visual loss in glaucoma is associated with pathological changes in retinal
ganglion cell (RGC) axons and a slow decline in the RGC population. Age and elevated …
ganglion cell (RGC) axons and a slow decline in the RGC population. Age and elevated …
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
Mutations in myocilin (MYOC) are the most common genetic cause of primary open angle
glaucoma (POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully …
glaucoma (POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully …