L-serine is a nonessential amino acid in eukaryotic cells, used for protein synthesis and in
producing phosphoglycerides, glycerides, sphingolipids, phosphatidylserine, and …

Organisms from all kingdoms of life synthesize L‐serine (L‐Ser) from 3‐phosphoglycerate
through the phosphorylated pathway, a three‐step diversion of glycolysis. Phosphoserine …

Pyridoxal phosphate-dependent enzymes able to use oxygen as a co-substrate have
emerged in multiple protein families. Here, we use crystallography to solve the 2.40 Å …

Reduced activity of the enzymes encoded by PHGDH, PSAT1, and PSPH causes a set of
ultrarare, autosomal recessive diseases known as serine biosynthesis defects. These …

Amoebiasis, a widespread disease caused by the protozoan parasite Entamoeba histolytica,
poses challenges due to the adverse effects of existing antiamoebic drugs and rising drug …

Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate-dependent enzyme
involved in the second step of the phosphorylated pathway of serine biosynthesis. PSAT …

Background Pathogenic variants in PHGDH, PSAT1, and PSPH cause a set of rare,
autosomal recessive diseases known as serine biosynthesis defects. Serine biosynthesis …

Pyridoxal 5'-phosphate (PLP) functions as a cofactor for hundreds of different enzymes that
are crucial to the survival of microorganisms. PLP-dependent enzymes have been …

Advancements in high-throughput sequencing technologies have accelerated the discovery
of human genetic variation. However, leveraging genomic information for precision medicine …

The growth, survival, and virulence of the microaerophilic protozoan Entamoeba histolytica
are correlated with its redox power and expression of its anti-oxidative enzymes. Thus, the …