CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Chloride channels represent a relatively under-explored target class for drug discovery as
elucidation of their identity and physiological roles has lagged behind that of many other …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

In the human genome more than 400 genes encode ion channels, which are
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …

Flufenamic acid has been known since the 1960s to have anti-inflammatory properties
attributable to the reduction of prostaglandin synthesis. Thirty years later, flufenamic acid …

Proteins of the CLC gene family assemble to homo-or sometimes heterodimers and either
function as Cl–channels or as Cl–/H+-exchangers. CLC proteins are present in all phyla …

Chloride transport across cell membranes is broadly involved in epithelial fluid transport, cell
volume and pH regulation, muscle contraction, membrane excitability, and organellar …

ClC-K channels form a subgroup of anion channels within the ClC family of anion transport
proteins. They are expressed predominantly in the kidney and in the inner ear, and are …

More than 400 genes are known that encode ion channel subunits. In addition, alternative
splicing and heteromeric assembly of different subunits increase tremendously the variety of …

Myotonia congenita (MC) is caused by loss-of-function mutations of the muscle ClC-1
chloride channel. Clinical manifestations include the variable association of myotonia and …