Low molecular weight synthetic peptides have been demonstrated to be effective catalysts
for an increasingly wide array of asymmetric transformations. In many cases, these peptide …

Reverse transcriptase (RT) plays an indispensable role in the replication of human
immunodeficiency virus (HIV) through its associated polymerase and ribonuclease H …

Abstract Chronic Hepatitis B virus (HBV) infection is a major worldwide public health
problem. Current direct-acting anti-HBV drugs target the HBV DNA polymerase activity, but …

The renewed interest in troponoid compounds as potential therapeutic agents and the
ongoing discovery of new, naturally occurring and biologically active members of the class …

Enolase is a glycolytic metalloenzyme involved in carbon metabolism. The advantage of
targeting enolase lies in its essentiality in many biological processes such as cell wall …

3, 7-Dihydroxytropolones (3, 7-dHTs) are highly oxygenated troponoids that have been
identified as lead compounds for several human diseases. To date, structure–function …

Polyoxygenated tropolones possess a broad range of biological activity, and as a result are
promising lead structures or fragments for drug development. However, structure–function …

The racemic modification of the α-tropolone-containing sesquiterpene olaximbriside A
[viz.(±)-4)] has been prepared over 12 steps from the readily accessible decalin derivative …

Abstract α-Hydroxytropolones (αHTs) are excellent metalloenzyme-inhibiting fragments that
have been the basis for the development of potent inhibitors of various therapeutically …

The α-hydroxytropolones (αHTs) are troponoid inhibitors of hepatitis B virus (HBV)
replication that can target HBV RNase H with submicromolar efficacies. αHTs and related …