Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …

More than 25 years after its discovery, the post-transcriptional gene regulation mechanism
termed RNAi is now transforming pharmaceutical development, proved by the recent FDA …

Summary N 6-methyladenosine (m 6 A) modification of mRNA is emerging as a vital
mechanism regulating RNA function. Here, we show that fragile X mental retardation protein …

Despite the prominent role of TDP-43 in neurodegeneration, its physiological and
pathological functions are not fully understood. Here, we report an unexpected role of TDP …

The significance of 5-methylcytosine (m5C) methylation in human malignancies has become
an increasing focus of investigation. Here, we show that m5C regulators including writers …

Steps of mRNA maturation are important gene regulatory events that occur in distinct cellular
locations. However, transcriptomic analyses often lose information on the subcellular …

Current models posit that nuclear speckles (NSs) serve as reservoirs of splicing factors and
facilitate posttranscriptional mRNA processing. Here, we discovered that ribotoxic stress …

Biomolecular condensates concentrate molecules to facilitate basic biochemical processes,
including transcription and DNA replication. While liquid-like condensates have been …

Eukaryotic cells contain sub-cellular compartments that are not membrane bound. Some
structures are always present, such as nuclear speckles that contain RNA-binding proteins …

The footprint of human endogenous retroviruses (HERV), specifically HERV-K, has been
found in malignancies, such as melanoma, teratocarcinoma, osteosarcoma, breast cancer …