Acquired immunodeficiency syndrome (AIDS), as a result of human immunodeficiency virus
(HIV) infection which leads to severe suppression of immune functions, is an enormous …

The widespread applications of benzophenone (BP) photochemistry in biological chemistry,
bioorganic chemistry, and material science have been prominent in both academic and …

The advent of soft-ionization mass spectrometry for biomolecules has opened up new
possibilities for the structural analysis of proteins. Combining protein chemistry methods with …

The multifunctional HIV-1 enzyme integrase interacts with viral DNA and its key cellular
cofactor LEDGF to effectively integrate the reverse transcript into a host cell chromosome …

tert-Butoxy-(4-phenyl-quinolin-3-yl)-acetic acids (tBPQA) are a new class of HIV-1 integrase
(IN) inhibitors that are structurally distinct from IN strand transfer inhibitors but analogous to …

HIV-1 integrase (IN) is the target for two classes of antiretrovirals: i) the integrase strand-
transfer inhibitors (INSTIs) and ii) the non-catalytic site integrase inhibitors (NCINIs). NCINIs …

Target identification is often the rate‐determining step in deciphering the mechanism of
action of biologically active small molecules. Photo‐affinity labeling (PAL) represents a …

We have identified oleuropein (Ole) and hydroxytyrosol (HT) as a unique class of HIV-1
inhibitors from olive leaf extracts effective against viral fusion and integration. We used …

The long process of HIV-1 integrase inhibitor discovery and development can be attributed
to both the complexity of HIV-1 integration and poor 'integration'of these researches into …

HIV integrates a DNA copy of its genome into a host cell chromosome in each replication
cycle. The essential DNA cleaving and joining chemistry of integration is known, but there is …