Delivery methods to increase cellular uptake and immunogenicity of DNA vaccines

SHT Jorritsma, EJ Gowans, B Grubor-Bauk… - Vaccine, 2016 - Elsevier
DNA vaccines are ideal candidates for global vaccination purposes because they are
inexpensive and easy to manufacture on a large scale such that even people living in low …

Lipid nanoparticles produce chimeric antigen receptor T cells with interleukin-6 knockdown in vivo

J Zhou, L Sun, Y Jia, Z Wang, T Luo, J Tan… - Journal of Controlled …, 2022 - Elsevier
Chimeric receptor T cells (CAR-T) can effectively cure leukemia; however, there are two
limitations: a complicated preparation process ex vivo and cytokine release syndrome …

pH sensitive liposomes assisted specific and improved breast cancer therapy using co-delivery of SIRT1 shRNA and Docetaxel

R Swami, Y Kumar, D Chaudhari, SS Katiyar… - Materials Science and …, 2021 - Elsevier
Combining the bio-therapeutics with chemotherapeutic drugs can assist in augmenting the
therapeutic standards by increasing the efficacy and decreasing the toxicity. Hence, in the …

Optimization of DOTAP/chol cationic lipid nanoparticles for mRNA, pDNA, and oligonucleotide delivery

M Sun, UJ Dang, Y Yuan, AM Psaras, O Osipitan… - AAPS …, 2022 - Springer
Lipid nanoparticles (LNPs) can be used as delivery vehicles for nucleic acid biotherapeutics.
In fact, LNPs are currently being used in the Pfizer/BioNTech and Moderna COVID-19 …

Influence of cationic lipid concentration on properties of lipid–polymer hybrid nanospheres for gene delivery

RJC Bose, Y Arai, JC Ahn, H Park… - International journal of …, 2015 - Taylor & Francis
Nanoparticles have been widely used for nonviral gene delivery. Recently, cationic hybrid
nanoparticles consisting of two different materials were suggested as a promising delivery …

EXOPLEXs: chimeric drug delivery platform from the fusion of cell-derived nanovesicles and liposomes

WJ Goh, S Zou, CK Lee, YH Ou, JW Wang… - …, 2018 - ACS Publications
Cell-derived nanovesicles (CDNs) have been recently investigated as novel drug delivery
systems (DDSs), due to the preservation of key features from the cell membrane of their …

The Potential Application of Branch‐PCR Assembled PTEN Gene Nanovector in Lung Cancer Gene Therapy

L Lu, T Fang, T Pang, Z Chen, L Cheng, D Ma… - …, 2022 - Wiley Online Library
Gene therapy offers an alternative and promising avenue to lung cancer treatment. Here, we
used dibenzocyclooctyne (DBCO)‐branched primers to construct a PTEN gene nanovector …

Development and characterization of a cationic lipid nanocarrier as non-viral vector for gene therapy

P Severino, M Szymanski, M Favaro, AR Azzoni… - European Journal of …, 2015 - Elsevier
The aim of the present work was to produce a cationic solid lipid nanoparticle (SLN) as non-
viral vector for protein delivery. Cationic SLN were produced by double emulsion method …

Inclusion of TAT and NLS sequences in lipopeptide molecules generates homogenous nanoparticles for gene delivery applications

S Pambudi, C Sriherwanto, AN Sasangka… - International Journal of …, 2024 - Elsevier
Purposes The objective of this study is to develop a versatile gene carrier based on
lipopeptides capable of delivering genetic material into target cells with minimal cytotoxicity …

Plasmid DNA hydrogels for biomedical applications

D Costa, AJM Valente, MG Miguel, J Queiroz - Advances in colloid and …, 2014 - Elsevier
In the last few years, our research group has focused on the design and development of
plasmid DNA (pDNA) based systems as devices to be used therapeutically in the biomedical …