Simple Summary Breast cancer is a concern for the healthcare system. Even with the
advancement of science and technology, the current system for therapeutics and diagnostics …

This review summarizes the in vivo assessment preliminary, preclinical, and clinical of
chemotherapeutics derived from camptothecin or a derivative. Camptothecin is a naturally …

The field of polymer therapeutics has evolved over the past decade and has resulted in the
development of polymer–drug conjugates with a wide variety of architectures and chemical …

The synthesis of polymer therapeutics capable of controlled loading and synchronized
release of multiple therapeutic agents remains a formidable challenge in drug delivery and …

Anticancer drugs embedded in or conjugated with inert nanocarriers, referred to as
nanomedicines, show many therapeutic advantages over free drugs, but the inert carrier …

Use of macromolecular water-soluble carriers of anti-cancer drugs represents a promising
approach to cancer therapy. Release of drugs from the carrier system is a prerequisite for …

This review provides a detailed discussion of recent advances in the medicinal chemistry of
camptothecin, a potent antitumor antibiotic. Two camptothecin analogues are presently …

The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a
unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled …

Camptothesome is an innovative nanovesicle therapeutic comprising the sphingomyelin-
derived camptothecin (CPT) lipid bilayer. In this work, we deciphered that Camptothesome …

The design, synthesis and properties of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics …