Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …
[HTML][HTML] Extracellular vesicles: The next generation in gene therapy delivery
Extracellular vesicles (EVs) are esteemed as a promising delivery vehicle for various genetic
therapeutics. They are relatively inert, non-immunogenic, biodegradable, and …
therapeutics. They are relatively inert, non-immunogenic, biodegradable, and …
Structure and function of cationic and ionizable lipids for nucleic acid delivery
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and
become major health issues, but the treatment development remains challenging. Gene …
become major health issues, but the treatment development remains challenging. Gene …
mRNA-based vaccines and therapeutics: An in-depth survey of current and upcoming clinical applications
YS Wang, M Kumari, GH Chen, MH Hong… - Journal of Biomedical …, 2023 - Springer
Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …
major challenge in realizing this drug class will promise to develop methods for safely …
Knife's edge: Balancing immunogenicity and reactogenicity in mRNA vaccines
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …
wield them in the development of therapeutics and vaccines. During the COVID-19 …
Outlook of pandemic preparedness in a post-COVID-19 world
BA Williams, CH Jones, V Welch, JM True - npj Vaccines, 2023 - nature.com
The COVID-19 pandemic was met with rapid, unprecedented global collaboration and
action. Even still, the public health, societal, and economic impact may be felt for years to …
action. Even still, the public health, societal, and economic impact may be felt for years to …
Strategies to reduce the risks of mRNA drug and vaccine toxicity
D Bitounis, E Jacquinet, MA Rogers… - Nature Reviews Drug …, 2024 - nature.com
Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …
enabled the rapid development and administration of billions of coronavirus disease 2019 …
[HTML][HTML] 'Spikeopathy': COVID-19 spike protein is pathogenic, from both virus and vaccine mRNA
PI Parry, A Lefringhausen, C Turni, CJ Neil, R Cosford… - Biomedicines, 2023 - mdpi.com
The COVID-19 pandemic caused much illness, many deaths, and profound disruption to
society. The production of 'safe and effective'vaccines was a key public health target. Sadly …
society. The production of 'safe and effective'vaccines was a key public health target. Sadly …
Approved nanomedicine against diseases
Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases.
Nanotechnology represents one of the most effective approaches in elevating a drug's …
Nanotechnology represents one of the most effective approaches in elevating a drug's …
Lipid nanoparticles optimized for targeting and release of nucleic acid
Y Jia, X Wang, L Li, F Li, J Zhang… - Advanced Materials, 2024 - Wiley Online Library
Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …